Emerging themes in medicinal glycoscience

被引:139
作者
Koeller, KM
Wong, CH
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
关键词
glycoconjugate; synthesis; therapeutic; antibiotic; vaccine;
D O I
10.1038/78435
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The recognition of complex carbohydrates and glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. New approaches for the simplification of glycoconjugate synthesis are overcoming the limitations of existing methods and providing a diverse array of these biomolecules. As the accessibility of glycoconjugates increases, carbohydrate-based constructs are becoming available for analysis as medicinal agents in a wide range of therapies.
引用
收藏
页码:835 / 841
页数:7
相关论文
共 117 条
[71]  
Ragupathi G, 1999, ANGEW CHEM INT EDIT, V38, P563, DOI 10.1002/(SICI)1521-3773(19990215)38:4<563::AID-ANIE563>3.0.CO
[72]  
2-3
[73]   Design, synthesis, and characterization of a high-affinity trivalent system derived from vancomycin and L-Lys-D-Ala-D-Ala [J].
Rao, JH ;
Lahiri, J ;
Weis, RM ;
Whitesides, GM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (12) :2698-2710
[74]   A trivalent system from vancomycin•D-Ala-D-Ala with higher affinity than avidin•biotin [J].
Rao, JH ;
Lahiri, J ;
Isaacs, L ;
Weis, RM ;
Whitesides, GM .
SCIENCE, 1998, 280 (5364) :708-711
[75]   Tight binding of a dimeric derivative of vancomycin with dimeric L-Lys-D-Ala-D-Ala [J].
Rao, JH ;
Whitesides, GM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (43) :10286-10290
[76]   Bacterial polysaccharide-protein conjugate vaccines [J].
Robbins, JB ;
Schneerson, R ;
Szu, SC ;
Pozsgay, V .
PURE AND APPLIED CHEMISTRY, 1999, 71 (05) :745-754
[77]   Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with theratope STn-KLH cancer vaccine [J].
Sandmaier, BM ;
Oparin, DV ;
Holmberg, LA ;
Reddish, MA ;
MacLean, GD ;
Longenecker, BM .
JOURNAL OF IMMUNOTHERAPY, 1999, 22 (01) :54-66
[78]   BIOSYNTHETIC CONTROLS THAT DETERMINE THE BRANCHING AND MICROHETEROGENEITY OF PROTEIN-BOUND OLIGOSACCHARIDES [J].
SCHACHTER, H .
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1986, 64 (03) :163-181
[79]  
Sears P, 1999, ANGEW CHEM INT EDIT, V38, P2301
[80]   Enzyme action in glycoprotein synthesis [J].
Sears, P ;
Wong, CH .
CELLULAR AND MOLECULAR LIFE SCIENCES, 1998, 54 (03) :223-252