Reduction of imines via titanium-catalyzed hydromagnesation

被引：12

作者：

Amin, SR ^{[1
]}

Crowe, WE ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)01797-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have recently discovered that imines can be reduced to amines via a titanium catalyzed hydromagnesation reaction. These reactions employ n-BuMgCl (1.2 eq) as the stoichiometric reducing agent and Cp2TiCl2 (3-5 mol%) as a catalyst. Reactions are run under nitrogen at ambient temperature and pressure. For most aldimine and cyclic ketimine substrates amine products are obtained in yields ranging from 69-94%. The reaction is not tolerant of bulky nitrogen substituents or primary enolizable protons on the imine substrate. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：7487 / 7490

页数：4

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