Stereoselective synthesis of novel anti-MRSA tricyclic carbapenems (trinems)

被引：31

作者：

Kanno, O ^{[1
]}

Kawamoto, I ^{[1
]}

机构：

[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 31期

关键词：

trinems; stereoselective synthesis; Mitsunobu reaction; MRSA;

D O I：

10.1016/S0040-4020(00)00413-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(4S)-Hydroxymethyltrinem 3 was prepared via stereoselective aldol-type reaction with optically pure (R)-2-t-butyldimethylsilyloxymethylcyclohexanone ((R)-16). (4S)-Hydroxymethyltrinem 3 was converted into various kinds of trinem derivatives with anti-MRSA activity by using the Mitsunobu reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5639 / 5648

页数：10

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