Chivosazole A -: Elucidation of the absolute and relative configuration

被引：61

作者：

Janssen, Dominic

Albert, Dieter

Jansen, Rolf

Mueller, Rolf

Kalesse, Markus

机构：

[1] Leibniz Univ Hannover, BMWZ, D-30167 Hannover, Germany

[2] Helmholtz Zentrum Infekt Forsch, D-38124 Braunschweig, Germany

[3] Univ Saarland, Inst Pharmazeut Biotechnol, D-66041 Saarbrucken, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 26期

关键词：

configuration determination; keto reductase; molecular modeling; natural products; NMR spectroscopy;

D O I：

10.1002/anie.200605198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The best of both worlds: The configurational assignment of a natural product - chivosazole A (1) isolated from myxobacteria - has been achieved for the first time through the combination of structure elucidation and genetic analysis. This was achieved by chemical degradation, analysis of the NMR data in combination with computer-aided conformation analysis, and assignment of the amino acid sequence. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4898 / 4901

页数：4

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