C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development

被引：31

作者：

Choy, S. W. ^{[1
]}

Wong, Y. M. ^{[1
]}

Ho, S. H. ^{[1
]}

Chow, K. L. ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 358卷 / 03期

关键词：

chromatin remodeling; mab-21; sin-3; ray patterning;

D O I：

10.1016/j.bbrc.2007.04.194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates. However, their mechanistic role on differentiation is largely unexplored. We report here the isolation of SIN-3 as a MAB-21 interacting molecule. sin-3 is co-expressed with mab-21 in the ray structural cells and genetically interacts with mab-21 to control sensory organ development. Using pharmacological and RNAi approaches, we demonstrated that historic deacetylase and conserved SIN-3-associated components are required for ray patterning. Conserved physical interactions between these components were also observed, implicating the recruitment of HDAC complex by MAB-21/SIN-3 may occur to determine ray identity in males. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：802 / 807

页数：6

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