Grignard cyclization reaction of fluorinated N-arylimidoyl chlorides:: A novel and facile access to 2-fluoroalkyl indoles

被引：24

作者：

Ge, Fenglian

Wang, Zengxue

Wan, Wen

Hao, Jian

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

SYNLETT | 2007年 / 03期

关键词：

fluorine-containing indoles; Grignard cyclizations; imidoyl chlorides; aryl amines; heterocycles;

D O I：

10.1055/s-2007-967950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Fluoroalkyl-substituted indole derivatives were simply prepared via the Grignard cyclization reaction (GCR) of corresponding fluorinated N-aryl imidoyl chlorides in good yields. This approach provides a novel and facile access to the biologically important 2-fluoroalkylindole derivatives.

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收藏

页码：447 / 450

页数：4

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