Rh(I)-catalyzed cyclization of 1-arylprop-2-yn-1-ol derivatives utilizing rhodium 1,4-migration

被引：100

作者：

Yamabe, H ^{[1
]}

Mizuno, A ^{[1
]}

Kusama, H ^{[1
]}

Iwasawa, N ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 10期

关键词：

D O I：

10.1021/ja042581o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly useful method for the construction of cyclopentanone derivatives fused with aromatic ring based on hydrorhodation-1,4-rhodium migration sequence is achieved. Treatment of 1-aryl-prop-2-yn-1-ols, which are easily accessible via an addition of acetylides to the corresponding aryl aldehydes, with a catalytic amount of [Rh(cod)2]2(BF4) and P(p-tolyl)3 in the presence of a base gives cyclopentanone derivatives in moderate to good yield. Copyright © 2005 American Chemical Society.

引用

页码：3248 / 3249

页数：2

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