Remyelination in multiple sclerosis

被引:135
作者
Brück, W [1 ]
Kuhlmann, T [1 ]
Stadelmann, C [1 ]
机构
[1] Humboldt Univ, Charite, Inst Neuropathol, D-13353 Berlin, Germany
关键词
multiple sclerosis; remyelination; oligodendrocytes; MRI;
D O I
10.1016/s0022-510x(02)00191-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined. The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:181 / 185
页数:5
相关论文
共 60 条
  • [1] ALLEN IV, 1991, MCALPINES MULTIPLE S, V2, P341
  • [2] A unique population of circulating autoantibodies promotes central nervous system remyelination
    Asakura, K
    Rodriguez, M
    [J]. MULTIPLE SCLEROSIS, 1998, 4 (03): : 217 - 221
  • [3] Imaging of remyelination
    Barkhof, F
    [J]. MULTIPLE SCLEROSIS, 1997, 3 (02): : 129 - 132
  • [4] Bitsch A, 1999, AM J NEURORADIOL, V20, P1619
  • [5] A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
    Bitsch, A
    Kuhlmann, T
    Stadelmann, C
    Lassmann, H
    Lucchinetti, C
    Brück, W
    [J]. ANNALS OF NEUROLOGY, 2001, 49 (06) : 793 - 796
  • [6] Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS
    Blakemore, WF
    Chari, DM
    Gilson, JM
    Crang, AJ
    [J]. GLIA, 2002, 38 (02) : 155 - 168
  • [7] MONOCYTE-MACROPHAGE DIFFERENTIATION IN EARLY MULTIPLE-SCLEROSIS LESIONS
    BRUCK, W
    PORADA, P
    POSER, S
    RIECKMANN, P
    HANEFELD, F
    KRETZSCHMAR, HA
    LASSMANN, H
    [J]. ANNALS OF NEUROLOGY, 1995, 38 (05) : 788 - 796
  • [8] OLIGODENDROCYTES IN THE EARLY COURSE OF MULTIPLE-SCLEROSIS
    BRUCK, W
    SCHMIED, M
    SUCHANEK, G
    BRUCK, Y
    BREITSCHOPF, H
    POSER, S
    PIDDLESDEN, S
    LASSMANN, H
    [J]. ANNALS OF NEUROLOGY, 1994, 35 (01) : 65 - 73
  • [9] Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination -: possible markers for an antibody-mediated process
    Brück, W
    Neubert, K
    Berger, T
    Weber, JR
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2001, 7 (03) : 173 - 177
  • [10] Embryonic stem cell-derived glial precursors:: A source of myelinating transplants
    Brüstle, O
    Jones, KN
    Learish, RD
    Karram, K
    Choudhary, K
    Wiestler, OD
    Duncan, ID
    McKay, RDG
    [J]. SCIENCE, 1999, 285 (5428) : 754 - 756