Unraveling the Structure of the Ribosome (Nobel Lecture)

被引:48
作者
Ramakrishnan, V. [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England
基金
英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院;
关键词
antibiotics; Nobel lecture; protein synthesis; ribosomes; AMINOACYL-TRANSFER-RNA; ELONGATION-FACTOR TU; FACTOR-EF-TU; PHENYLALANINE TRANSFER-RNA; ESCHERICHIA-COLI RIBOSOME; 5.5 ANGSTROM RESOLUTION; INITIATION-FACTOR IF3; CRYSTAL-STRUCTURE; 70S RIBOSOME; THERMUS-THERMOPHILUS;
D O I
10.1002/anie.201001436
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:4355 / 4380
页数:26
相关论文
共 104 条
[91]   Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process [J].
Valle, M ;
Sengupta, J ;
Swami, NK ;
Grassucci, RA ;
Burkhardt, N ;
Nierhaus, KH ;
Agrawal, RK ;
Frank, J .
EMBO JOURNAL, 2002, 21 (13) :3557-3567
[92]   Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis [J].
Villa, Elizabeth ;
Sengupta, Jayati ;
Trabuco, Leonardo G. ;
LeBarron, Jamie ;
Baxter, William T. ;
Shaikh, Tanvir R. ;
Grassucci, Robert A. ;
Nissen, Poul ;
Ehrenberg, Mans ;
Schulten, Klaus ;
Frank, Joachim .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (04) :1063-1068
[93]   CHARACTERIZATION AND PRELIMINARY ATTEMPTS FOR DERIVATIZATION OF CRYSTALS OF LARGE RIBOSOMAL-SUBUNITS FROM HALOARCULA-MARISMORTUI DIFFRACTING TO 3-A RESOLUTION [J].
VONBOHLEN, K ;
MAKOWSKI, I ;
HANSEN, HAS ;
BARTELS, H ;
BERKOVITCHYELLIN, Z ;
ZAYTZEVBASHAN, A ;
MEYER, S ;
PAULKE, C ;
FRANCESCHI, F ;
YONATH, A .
JOURNAL OF MOLECULAR BIOLOGY, 1991, 222 (01) :11-15
[94]   Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome [J].
Voorhees, Rebecca M. ;
Weixlbaumer, Albert ;
Loakes, David ;
Kelley, Ann C. ;
Ramakrishnan, V. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (05) :528-533
[95]  
WATSON JD, 1958, NATURE, V182, P778
[96]   STRUCTURE OF THE CALCIUM-DEPENDENT LECTIN DOMAIN FROM A RAT MANNOSE-BINDING PROTEIN DETERMINED BY MAD PHASING [J].
WEIS, WI ;
KAHN, R ;
FOURME, R ;
DRICKAMER, K ;
HENDRICKSON, WA .
SCIENCE, 1991, 254 (5038) :1608-1615
[97]   Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome [J].
Weixlbaumer, Albert ;
Jin, Hong ;
Neubauer, Cajetan ;
Voorhees, Rebecca M. ;
Petry, Sabine ;
Kelley, Ann C. ;
Ramakrishnan, Venki .
SCIENCE, 2008, 322 (5903) :953-956
[98]   Crystal structure of the ribosome recycling factor bound to the ribosome [J].
Weixlbaumer, Albert ;
Petry, Sabine ;
Dunham, Christine M. ;
Selmer, Maria ;
Kelley, Ann C. ;
Ramakrishnan, V. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (08) :733-737
[99]   Structure of the 30S ribosomal subunit [J].
Wimberly B.T. ;
Brodersen D.E. ;
Clemons Jr. W.M. ;
Morgan-Warren R.J. ;
Carter A.P. ;
Vonrheln C. ;
Hartsch T. ;
Ramakrishnan V. .
Nature, 2000, 407 (6802) :327-339
[100]  
Yarus Michael, 1995, P443