Nanoparticle interaction with biological membranes: Does nanotechnology present a janus face?

被引：440

作者：

Leroueil, Pascale R.

Hong, Seungpyo

Mecke, Almut

Baker, James R., Jr.

Orr, Bradford G.

Holl, Mark M. Banaszak ^{[1
]}

机构：

[1] Univ Michigan, Graham Environm Sustainabil Inst, Dept Chem, Program Macromol Sci & Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Graham Environm Sustainabil Inst, Dept Phys, Program Macromol Sci & Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2007年 / 40卷 / 05期

关键词：

D O I：

10.1021/ar600012y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phase-fluid, liquid crystalline, or gel-of the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.

引用

页码：335 / 342

页数：8

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