Chromatin structure and the inheritance of epigenetic information

被引：529

作者：

Margueron, Raphael ^{[1
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Sch Med, Howard Hughes Med Inst, Dept Biochem, New York, NY 10016 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 04期

基金：

美国国家卫生研究院;

关键词：

POSITION-EFFECT VARIEGATION; H3; LYSINE-9; METHYLATION; EMBRYONIC STEM-CELLS; HISTONE H3; DNA METHYLATION; DROSOPHILA-MELANOGASTER; NONCODING RNA; S-PHASE; HETEROCHROMATIN FORMATION; TRANSCRIPTIONAL MEMORY;

D O I：

10.1038/nrg2752

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying the epigenetic program, it is still unclear how a defined chromatin domain is reproduced following DNA replication and transmitted from one cell generation to the next. Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells. We consider models of how histones might be recycled following replication, and discuss the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states.

引用

页码：285 / 296

页数：12

共 114 条

[1] Noncoding RNA in development [J].

Amaral, Paulo P. ;

Mattick, John S. .

MAMMALIAN GENOME, 2008, 19 (7-8) :454-492

[2] A role for the CPF 3′-end processing machinery in RNAP II-dependent gene looping [J].

Ansari, A ;

Hampsey, M .

GENES & DEVELOPMENT, 2005, 19 (24) :2969-2978

[3] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[4] Inheritance of Polycomb-dependent chromosomal interactions in Drosophila [J].

Bantignies, F ;

Grimaud, C ;

Lavrov, S ;

Gabut, M ;

Cavalli, G .

GENES & DEVELOPMENT, 2003, 17 (19) :2406-2420

[5] Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin [J].

Bao, Xiaomin ;

Deng, Huai ;

Johansen, Jorgen ;

Girton, Jack ;

Johansen, Kristen M. .

GENETICS, 2007, 176 (02) :1355-1358

[6] An operational definition of epigenetics [J].

Berger, Shelley L. ;

Kouzarides, Tony ;

Shiekhattar, Ramin ;

Shilatifard, Ali .

GENES & DEVELOPMENT, 2009, 23 (07) :781-783

[7] Genome-Wide Association of Histone H3 Lysine Nine Methylation with CHG DNA Methylation in Arabidopsis thaliana [J].

Bernatavichute, Yana V. ;

Zhang, Xiaoyu ;

Cokus, Shawn ;

Pellegrini, Matteo ;

Jacobsen, Steven E. .

PLOS ONE, 2008, 3 (09)

[8] Preventing re-replication of chromosomal DNA [J].

Blow, JJ ;

Dutta, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486

[9] UHRF1 plays a role in maintaining DNA methylation in mammalian cells [J].

Bostick, Magnolia ;

Kim, Jong Kyong ;

Esteve, Pierre-Olivier ;

Clark, Amander ;

Pradhan, Sriharsa ;

Jacobsen, Steven E. .

SCIENCE, 2007, 317 (5845) :1760-1764

[10] H2A.z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state [J].

Brickner, Donna Garvey ;

Cajigas, Ivelisse ;

Fondufe-Mittendorf, Yvonne ;

Ahmed, Sara ;

Lee, Pei-Chih ;

Widom, Jonathan ;

Brickner, Jason H. .

PLOS BIOLOGY, 2007, 5 (04) :704-716

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