Chromatin structure and the inheritance of epigenetic information

被引：529

作者：

Margueron, Raphael ^{[1
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Sch Med, Howard Hughes Med Inst, Dept Biochem, New York, NY 10016 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 04期

基金：

美国国家卫生研究院;

关键词：

POSITION-EFFECT VARIEGATION; H3; LYSINE-9; METHYLATION; EMBRYONIC STEM-CELLS; HISTONE H3; DNA METHYLATION; DROSOPHILA-MELANOGASTER; NONCODING RNA; S-PHASE; HETEROCHROMATIN FORMATION; TRANSCRIPTIONAL MEMORY;

D O I：

10.1038/nrg2752

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying the epigenetic program, it is still unclear how a defined chromatin domain is reproduced following DNA replication and transmitted from one cell generation to the next. Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells. We consider models of how histones might be recycled following replication, and discuss the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states.

引用

页码：285 / 296

页数：12

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