Treatment with α-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus

被引:21
作者
Mittermayer, Friedrich [1 ]
Pleiner, Johannes [1 ]
Francesconi, Mario [2 ]
Wolzt, Michael [1 ]
机构
[1] Med Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria
[2] Rehabil Ctr Alland, Alland, Austria
关键词
STAGE RENAL-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS; ARTERY-DISEASE; DIMETHYLAMINOHYDROLASE; DECREASES; MORTALITY; PATHWAY;
D O I
10.1016/j.trsl.2009.08.004
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Elevated asymmetric dimethylarginine (ADMA) concentrations predict cardiovascular events in patients with type 2 diabetes mellitus (T2DM). It has been shown that a-lipoic acid (ALA) improves endothelial function and oxidative stress in these patients. The present study investigated if ALA reduces ADMA in patients with T2DM. Plasma concentrations of ADMA, L-arginine and symmetric dimethylarginine (SDMA) were determined in a double-blind, randomized, placebo-controlled study in patients with T2DM. Intravenous ALA (n = 16) or placebo (n = 14) was administered daily for 3 weeks. ALA reduced ADMA while no change was observed with placebo (mean change -0.05 mu mol/1[95% CI: -0.01; -0.09] vs. 0.01 mu mol/1 [95% CI: -0.05; -0.03]; ANOVA p = 0.031). SDMA and L-arginine were not affected by ALA. In conclusion ALA treatment reduces ADMA in patients with T2DM. Long-term studies need to demonstrate if ALA may cause cardiovascular risk reduction. (Translational Research 2010;155:6-9)
引用
收藏
页码:6 / 9
页数:4
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