Synthesis of arylplatinum(II) complexes with chiral monoanionic aryldiamine ligands.: The X-ray crystal structure of (-)-[(1R,1′R)-2,6-bis{1-(dimethylamino)propyl}-phenyl]chloroplatinum(II)

The new chiral arylplatinum(II) compounds [2,6-bis(1-(dimethylamino)ethyl)phenyl]chloroplatinum (4) and (-)-[(1R,1'R)-bis(1-(dimethylamino)propyl)phenyl]chloroplatinum(II) (5) have been synthesized. The transmetallation of the corresponding aryllithium compounds does not affect either stereogenic centres of the organic ligand while the rate of the transmetallation is shown to be influenced by the size of the benzylic substituents. The X-ray crystal structure of 5 is reported from which the absolute configuration of both stereogenic centres of the organic ligand was determined to be (R). (C) 1998 Elsevier Science B.V.