Tau aggregation into fibrillar polymers: taupathies

被引：76

作者：

Avila, J ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

tau protein; assembly; neurodegeneration; Alzheimer's disease;

D O I：

10.1016/S0014-5793(00)01676-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Different neurological disorders, known as taupathies have been recently described. In these disorders it has been suggested that modifications in the microtubule-associated protein tau could cause neural degeneration in specific regions. Although these regions are different in the different taupathies, some common features appear to occur in all of them: abnormal hyperphosphorylation of tau and aberrant tau aggregation. These two features are commented upon in this review. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：89 / 92

页数：4

共 60 条

[11] Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease [J].

Brückner, G ;

Hausen, D ;

Härtig, W ;

Drlicek, M ;

Arendt, T ;

Brauer, K .

NEUROSCIENCE, 1999, 92 (03) :791-805

[12] INHIBITION OF NEURITE POLARITY BY TAU ANTISENSE OLIGONUCLEOTIDES IN PRIMARY CEREBELLAR NEURONS [J].

CACERES, A ;

KOSIK, KS .

NATURE, 1990, 343 (6257) :461-463

[13]

CORREAS I, 1992, J BIOL CHEM, V267, P15721

[14] ASSEMBLY OF ALZHEIMER-LIKE FILAMENTS FROM FULL-LENGTH TAU-PROTEIN [J].

CROWTHER, RA ;

OLESEN, OF ;

SMITH, MJ ;

JAKES, R ;

GOEDERT, M .

FEBS LETTERS, 1994, 337 (02) :135-138

[15] TAU-FACTOR POLYMERS ARE SIMILAR TO PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE [J].

DEGARCINI, EM ;

CARRASCOSA, JL ;

CORREAS, I ;

NIETO, A ;

AVILA, J .

FEBS LETTERS, 1988, 236 (01) :150-154

[16] The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease [J].

Delacourte, A ;

David, JP ;

Sergeant, N ;

Buée, L ;

Wattez, A ;

Vermersch, P ;

Ghozali, F ;

Fallet-Bianco, C ;

Pasquier, F ;

Lebert, F ;

Petit, H ;

Di Menza, C .

NEUROLOGY, 1999, 52 (06) :1158-1165

[17] TAU-PROTEIN FUNCTION IN LIVING CELLS [J].

DRUBIN, DG ;

KIRSCHNER, MW .

JOURNAL OF CELL BIOLOGY, 1986, 103 (06) :2739-2746

[18] Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments [J].

Goedert, M ;

Jakes, R ;

Crowther, RA .

FEBS LETTERS, 1999, 450 (03) :306-311

[19] Filamentous nerve cell inclusions in neurodegenerative diseases:: tauopathies and α-synucleinopathies [J].

Goedert, M .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1999, 354 (1386) :1101-1118

[20] Filamentous nerve cell inclusions in neurodegenerative diseases [J].

Goedert, M ;

Spillantini, MG ;

Davies, SW .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (05) :619-632

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