Uncatalyzed Michael addition of indoles: synthesis of some novel 3-alkylated indoles via a three-component reaction in solvent-free conditions

被引：50

作者：

Deb, Mohit L. ^{[1
]}

Bhuyan, Pulak J. ^{[1
]}

机构：

[1] Reg Res Lab, Div Med Chem, Jorhat 785006, Assam, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 12期

关键词：

indoles; Michael addition; pyrimidines; solvent-free reaction; multicomponent reaction;

D O I：

10.1016/j.tetlet.2007.01.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of some novel 3-alkylated indoles via an uncatalyzed Michael addition of indoles using three components in one-pot solvent-free conditions is reported. The mechanism was established by performing the reaction in two steps. The reaction was also studied in different solvents and an important solvent effect was noticed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2159 / 2163

页数：5

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