DNA methylation with a sting: an active DNA methylation system in the honeybee

被引：28

作者：

Schaefer, Matthias ^{[1
]}

Lyko, Frank ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, Div Epigenet, D-69120 Heidelberg, Germany

来源：

BIOESSAYS | 2007年 / 29卷 / 03期

关键词：

D O I：

10.1002/bies.20548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The existence of DNA methylation in insects has been a controversial subject over a long period of time. The recently completed genome sequence of the honeybee Apis mellitera has revealed the first insect with a full complement of DNA methyltransferases.((1)) A parallel study demonstrated that these enzymes are catalytically active and that Apis genes can be methylated in specific patterns.((2)) These findings establish bees as a model to analyze the function of DNA methylation systems in invertebrate organisms and might also be important to understand evolutionary aspects of DNA methylation in higher eukaryotes.

引用

页码：208 / 211

页数：4

共 26 条

[1] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[2] DNA methyltransferases get connected to chromatin [J].

Burgers, WA ;

Fuks, F ;

Kouzarides, T .

TRENDS IN GENETICS, 2002, 18 (06) :275-277

[3] Characterization of cytosine methylated regions and 5-cytosine DNA methyltransferase (Ehmeth) in the protozoan parasite Entamoeba histolytica [J].

Fisher, O ;

Siman-Tov, R ;

Ankri, S .

NUCLEIC ACIDS RESEARCH, 2004, 32 (01) :287-297

[4] Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS) [J].

Frigola, J ;

Ribas, M ;

Risques, RA ;

Peinado, MA .

NUCLEIC ACIDS RESEARCH, 2002, 30 (07) :e28

[5] Eukaryotic cytosine methyltransferases [J].

Goll, MG ;

Bestor, TH .

ANNUAL REVIEW OF BIOCHEMISTRY, 2005, 74 :481-514

[6] Methylation of tRNAAsP by the DNA methyltransferase homolog Dnmt2 [J].

Goll, MG ;

Kirpekar, F ;

Maggert, KA ;

Yoder, JA ;

Hsieh, CL ;

Zhang, XY ;

Golic, KG ;

Jacobsen, SE ;

Bestor, TH .

SCIENCE, 2006, 311 (5759) :395-398

[7] Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae [J].

Gutierrez, A ;

Sommer, RJ .

NUCLEIC ACIDS RESEARCH, 2004, 32 (21) :6388-6396

[8] Genomic imprinting and kinship: How good is the evidence? [J].

Haig, D .

ANNUAL REVIEW OF GENETICS, 2004, 38 :553-585

[9] The methyl-CpG binding domain and the evolving role of DNA methylation in animals [J].

Hendrich, B ;

Tweedie, S .

TRENDS IN GENETICS, 2003, 19 (05) :269-277

[10] Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals [J].

Jaenisch, R ;

Bird, A .

NATURE GENETICS, 2003, 33 (Suppl 3) :245-254

← 1 2 3 →