Molecular determinants of Listeria monocytogenes virulence

被引:203
作者
Dussurget, O [1 ]
Pizarro-Cerda, J [1 ]
Cossart, P [1 ]
机构
[1] Inst Pasteur, INSERM, U604, Unite Interact Bacteries Cellules, F-75015 Paris, France
关键词
infectious cycle; virulence factors; genomes; pathophysiology;
D O I
10.1146/annurev.micro.57.030502.090934
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.
引用
收藏
页码:587 / 610
页数:24
相关论文
共 133 条
  • [11] Listeria protein ActA mimics WASP family proteins: It activates filament barbed end branching by Arp2/3 complex
    Boujemaa-Paterski, R
    Gouin, E
    Hansen, G
    Samarin, S
    Le Clainche, C
    Didry, D
    Dehoux, P
    Cossart, P
    Kocks, C
    Carlier, MF
    Pantaloni, D
    [J]. BIOCHEMISTRY, 2001, 40 (38) : 11390 - 11404
  • [12] gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes
    Braun, L
    Ghebrehiwet, B
    Cossart, P
    [J]. EMBO JOURNAL, 2000, 19 (07) : 1458 - 1466
  • [13] The 213-amino-acid leucine-rich repeat region of the Listeria monocytogenes InIB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling
    Braun, L
    Nato, F
    Payrastre, B
    Mazié, JC
    Cossart, P
    [J]. MOLECULAR MICROBIOLOGY, 1999, 34 (01) : 10 - 23
  • [14] The InIB protein of Listeria monocytogenes is sufficient to promote entry into mammalian cells
    Braun, L
    Ohayon, H
    Cossart, P
    [J]. MOLECULAR MICROBIOLOGY, 1998, 27 (05) : 1077 - 1087
  • [15] InIB: an invasion protein of Listeria monocytogenes with a novel type of surface association
    Braun, L
    Dramsi, S
    Dehoux, P
    Bierne, H
    Lindahl, G
    Cossart, P
    [J]. MOLECULAR MICROBIOLOGY, 1997, 25 (02) : 285 - 294
  • [16] STRUCTURAL AND FUNCTIONAL-PROPERTIES OF THE P60 PROTEINS FROM DIFFERENT LISTERIA SPECIES
    BUBERT, A
    KUHN, M
    GOEBEL, W
    KOHLER, S
    [J]. JOURNAL OF BACTERIOLOGY, 1992, 174 (24) : 8166 - 8171
  • [17] Comparison of the genome sequences of Listeria monocytogenes and Listeria innocua:: clues for evolution and pathogenicity
    Buchrieser, C
    Rusniok, C
    Kunst, F
    Cossart, P
    Glaser, P
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2003, 35 (03): : 207 - 213
  • [18] Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection
    Busch, DH
    Kerksiek, K
    Pamer, EG
    [J]. IMMUNOLOGICAL REVIEWS, 1999, 172 : 163 - 169
  • [19] Auto, a surface associated autolysin of Listeria monocytogenes required for entry into eukaryotic cells and virulence
    Cabanes, D
    Dussurget, O
    Dehoux, P
    Cossart, P
    [J]. MOLECULAR MICROBIOLOGY, 2004, 51 (06) : 1601 - 1614
  • [20] Surface proteins and the pathogenic potential of Listeria monocytogenes
    Cabanes, D
    Dehoux, P
    Dussurget, O
    Frangeul, L
    Cossart, P
    [J]. TRENDS IN MICROBIOLOGY, 2002, 10 (05) : 238 - +