Molecular determinants of Listeria monocytogenes virulence

被引：203

作者：

Dussurget, O ^{[1
]}

Pizarro-Cerda, J ^{[1
]}

Cossart, P ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, U604, Unite Interact Bacteries Cellules, F-75015 Paris, France

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2004年 / 58卷

关键词：

infectious cycle; virulence factors; genomes; pathophysiology;

D O I：

10.1146/annurev.micro.57.030502.090934

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.

引用

页码：587 / 610

页数：24

共 133 条

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