Sex and death: What is the connection?

被引：341

作者：

Partridge, L

Gems, D

Withers, DJ

机构：

[1] UCL, Ctr Res Ageing, Dept Biol, London WC1E 6BT, England

[2] UCL, Rayne Inst, Ctr Diabet & Endocrinol, London, England

来源：

CELL | 2005年 / 120卷 / 04期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.cell.2005.01.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.

引用

页码：461 / 472

页数：12

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