Novel PDGF family members: PDGF-C and PDGF-D

被引：149

作者：

Li, XR ^{[1
]}

Eriksson, U ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Stockholm Branch, S-17177 Stockholm, Sweden

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 02期

关键词：

PDGF; mesenchymal origin; pathophysiological process;

D O I：

10.1016/S1359-6101(02)00090-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-derived growth factors (PDGFs) were discovered almost two decades ago. The classical PDGF polypeptide chains, PDGF-A and PDGF-B, are well studied and they regulate a number of physiological and pathophysiological processes in many types of mesenchymal cells via two receptor tyrosine kinases, PDGF receptors alpha and beta. Recently, two additional PDGF polypeptide chains were discovered, namely PDGF-C and PDGF-D. The discovery of two additional ligands for the two PDGF receptors suggests that PDGF-mediated signaling is more complex than previously anticipated. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：91 / 98

页数：8

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