Novel PDGF family members: PDGF-C and PDGF-D

被引：149

作者：

Li, XR ^{[1
]}

Eriksson, U ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Stockholm Branch, S-17177 Stockholm, Sweden

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 02期

关键词：

PDGF; mesenchymal origin; pathophysiological process;

D O I：

10.1016/S1359-6101(02)00090-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-derived growth factors (PDGFs) were discovered almost two decades ago. The classical PDGF polypeptide chains, PDGF-A and PDGF-B, are well studied and they regulate a number of physiological and pathophysiological processes in many types of mesenchymal cells via two receptor tyrosine kinases, PDGF receptors alpha and beta. Recently, two additional PDGF polypeptide chains were discovered, namely PDGF-C and PDGF-D. The discovery of two additional ligands for the two PDGF receptors suggests that PDGF-mediated signaling is more complex than previously anticipated. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：91 / 98

页数：8

共 48 条

[21] Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice [J].

Gnessi, L ;

Basciani, S ;

Mariani, S ;

Arizzi, M ;

Spera, G ;

Wang, CY ;

Bondjers, C ;

Karlsson, L ;

Betsholtz, C .

JOURNAL OF CELL BIOLOGY, 2000, 149 (05) :1019-1025

[22] The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system [J].

Hamada, T ;

Ui-Tei, K ;

Imaki, J ;

Takahashi, F ;

Onodera, H ;

Mishima, T ;

Miyata, Y .

MECHANISMS OF DEVELOPMENT, 2002, 112 (1-2) :161-164

[23] Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein [J].

Hamada, T ;

Ui-Tei, K ;

Imaki, J ;

Miyata, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (03) :733-737

[24] Mechanism of action and in vivo role of platelet-derived growth factor [J].

Heldin, CH ;

Westermark, B .

PHYSIOLOGICAL REVIEWS, 1999, 79 (04) :1283-1316

[25] THE C-SIS GENE ENCODES A PRECURSOR OF THE B-CHAIN OF PLATELET-DERIVED GROWTH-FACTOR [J].

JOHNSSON, A ;

HELDIN, CH ;

WASTESON, A ;

WESTERMARK, B ;

DEUEL, TF ;

HUANG, JS ;

SEEBURG, PH ;

GRAY, A ;

ULLRICH, A ;

SCRACE, G ;

STROOBANT, P ;

WATERFIELD, MD .

EMBO JOURNAL, 1984, 3 (05) :921-928

[26]

Karlsson L, 2000, DEVELOPMENT, V127, P3457

[27]

Karlsson L, 1999, DEVELOPMENT, V126, P2611

[28]

Kawai T, 1997, LAB INVEST, V77, P431

[29] PDGFD, a new protease-activated growth factor [J].

LaRochelle, WJ ;

Jeffers, M ;

McDonald, WF ;

Chillakuru, RA ;

Giese, NA ;

Lokker, NA ;

Sullivan, C ;

Boldog, FL ;

Yang, MJ ;

Vernet, C ;

Burgess, CE ;

Fernandes, E ;

Deegler, LL ;

Rittman, B ;

Shimkets, J ;

Shimkets, RA ;

Rothberg, JM ;

Lichenstein, HS .

NATURE CELL BIOLOGY, 2001, 3 (05) :517-521

[30]

LAROCHELLE WJ, 1908, CANCER RES, V62, P2468

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