Lipase-catalyzed kinetic resolution of racemic seven-membered substituted lactones

被引：17

作者：

Shioji, K ^{[1
]}

Matsuo, A

Okuma, K

Nakamura, K

Ohno, A

机构：

[1] Fukuoka Univ, Fac Sci, Dept Chem, Jonan ku, Fukuoka 8140180, Japan

[2] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 45期

关键词：

enzymes and enzyme reaction; hydrolysis; lactone;

D O I：

10.1016/S0040-4039(00)01421-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active 3-, 4-, 5-, or 6-methyl substituted seven-membered lactones were prepared by Candida antarctica lipase (CAL)-catalyzed kinetic resolution of the racemic lactones. Among these lactones, only in the case of 5-methylhexanolide (R)-isomer reacts faster than the other enantiomer, while the rest of lactones show (S)-selectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8799 / 8802

页数：4

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