The growing applications of click chemistry

被引：2157

作者：

Moses, John E. ^{[1
]}

Moorhouse, Adam D. ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 08期

关键词：

IN-SITU; SOLID-PHASE; DIELS-ALDER; LIGATION; INHIBITORS; POLYMERS; LIGANDS; FUNCTIONALIZATION; CYCLOADDITIONS; STABILIZATION;

D O I：

10.1039/b613014n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.

引用

页码：1249 / 1262

页数：14

共 45 条

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