Mesoporous silica nanoparticles deliver DNA and chemicals into plants

被引：941

作者：

Torney, Francois

Trewyn, Brian G.

Lin, Victor S. -Y. ^{[1
]}

Wang, Kan

机构：

[1] Iowa State Univ, Ctr Plant Transformat, Inst Plant Sci, Ames, IA 50011 USA

[2] Iowa State Univ, Dept Agron, Ames, IA 50011 USA

[3] Iowa State Univ, Dept Chem, US DOE, Ames Lab, Ames, IA 50011 USA

来源：

NATURE NANOTECHNOLOGY | 2007年 / 2卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nnano.2007.108

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Surface-functionalized silica nanoparticles can deliver DNA(1-8) and drugs(9-15) into animal cells and tissues. However, their use in plants is limited by the cell wall present in plant cells. Here we show a honeycomb mesoporous silica nanoparticle (MSN) system with 3-nm pores that can transport DNA and chemicals into isolated plant cells and intact leaves. We loaded the MSN with the gene and its chemical inducer and capped the ends with gold nanoparticles to keep the molecules from leaching out. Uncapping the gold nanoparticles released the chemicals and triggered gene expression in the plants under controlled-release conditions. Further developments such as pore enlargement and multifunctionalization of these MSNs may offer new possibilities in target-specific delivery of proteins, nucleotides and chemicals in plant biotechnology.

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页码：295 / 300

页数：6

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