The Chd family of chromatin remodelers

被引：290

作者：

Marfella, Concetta G. A. ^{[1
]}

Imbalzano, Anthony N. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2007年 / 618卷 / 1-2期

关键词：

chromodomain helicase DNA-binding (CHD) family; ATPase; chromatin remodeling; SNF2; family; transcription elongation; development; differentiation and disease;

D O I：

10.1016/j.mrfmmm.2006.07.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：30 / 40

页数：11

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