Glycosyltransferases in the synthesis of oligosaccharide analogs

被引：66

作者：

Palcic, MM ^{[1
]}

Hindsgaul, O ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT CHEM, EDMONTON, AB T6G 2G2, CANADA

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 1996年 / 8卷 / 39期

关键词：

enzymatic synthesis; glycosyltransferases; oligosaccharide analogs;

D O I：

10.4052/tigg.8.37

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The glycosyltransferase-mediated synthesis of oligosaccharide analogs is reviewed, with emphasis on the use of modified sugar-nucleotide donors or modified accepters as substrates. A survey of the most studied enzymes: beta(1-->4)-galactosyltransferase, N-Acetylglucosaminyltransferase I, alpha(1-->3/4)-fucosyltransferases and alpha(2-->3 or 2-->6)-sialyltransferases, shows them to be very useful for the rapid production of chemically modified di-, tri- and tetrasaccharide analogs.

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收藏

页码：37 / 49

页数：13

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