Acceleration of virus-induced apoptosis by tumor necrosis factor

被引：24

作者：

Koyama, AH ^{[1
]}

Arakawa, T

Adachi, A

机构：

[1] Univ Tokushima, Sch Med, Dept Virol, Tokushima 770, Japan

[2] Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

FEBS LETTERS | 1998年 / 426卷 / 02期

关键词：

tumor necrosis factor; apoptosis; vesicular stomatitis virus;

D O I：

10.1016/S0014-5793(98)00338-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The multiplication of vesicular stomatitis virus in HeLa cells was inhibited by treating the cells with tumor necrosis factor (TNF), Comparison of the kinetics of virus multiplication and that of virus-induced apoptosis in the TNF-treated cells revealed that the antiviral effect of TNF is accompanied by a rapid induction of apoptosis in the cells upon infection, suggesting that TNF can inhibit virus multiplication by accelerating an apoptotic response in the infected cells. (C) 1998 Federation of European Biochemical Societies.

引用

页码：179 / 182

页数：4

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