Antidepressant effects of high and low frequency repetitive transcranial magnetic stimulation to the dorsolateral prefrontal cortex: A double-blind, randomized, placebo-controlled trial

被引：99

作者：

Stern, William M. ^{[1
]}

Tormos, Jose Maria ^{[1
]}

Press, Daniel Z. ^{[1
]}

Pearlman, C. ^{[1
]}

Pascual-Leone, Alvaro ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2007年 / 19卷 / 02期

关键词：

D O I：

10.1176/appi.neuropsych.19.2.179

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Repetitive transcranial magnetic stimulation (rTMS) has antidepressant effects in patients with major depressive disorder. The mechanisms of action and optimal stimulation parameters remain unclear. To test the hypothesis that rTMS exerts antidepressant effects either by enhancing left dorsolateral prefrontal cortex (DLPFC) excitability or by decreasing right DLPFC excitability, the authors studied 45 patients with unipolar recurrent major depressive disorder in a double-blind, randomized, parallel group, sham-controlled trial. Patients were randomized to receive 1 Hz or 10 Hz rTMS to the left DLPFC, 1 Hz to the right DLPFC or sham TMS. Left 10 Hz and right 1 Hz rTMS showed similar significant antidepressant effects. Other parameters led to no significant antidepressant effects.

引用

页码：179 / 186

页数：8

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