Immune response characteristics following emergency vaccination of pigs against foot-and-mouth disease

被引：30

作者：

Barnard, AL

Arriens, A

Cox, S

Barnett, P

Kristensen, B

Summerfield, A

McCullough, KC ^{[1
]}

机构：

[1] Inst Virol & Immunoprophylaxis, Dept Immunol, CH-3147 Mittelhausern, Switzerland

[2] Inst Anim Hlth, Woking GU2 40NF, Surrey, England

[3] Royal Vet & Agr Univ, Lab Virol & Immunol, DK-1870 Frederiksberg C, Denmark

来源：

VACCINE | 2005年 / 23卷 / 08期

关键词：

FMDV; emergency-vaccination; Th1/Th2-responses;

D O I：

10.1016/j.vaccine.2004.07.034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pigs were vaccinated with the emergency inactivated foot-and-mouth disease virus (FMDV) vaccine-water-in-oil-in-water emulsion with Montanide ISA206-known to protect after 3-5 days. Peripheral blood leukocyte (PBL) sub-populations did not differ between vaccinates and controls post-vaccination. There was neither lymphopenia nor inflammatory reaction. FMDV-specific antibody and T lymphocyte activity developed in the vaccinates. Virus-induced Th1-like cytokine protein and mRNA (IFNgamma and IL-2) were identified, particularly IFNgamma. Th2-like cytokine protein and mRNA (IL-4 and IL-6) were also induced in an FMDV-specific manner. IL-10 was induced by both virus and mock antigen. The current emergency FMDV vaccine induces a diverse immune defence network-innate. and both Th1-like and Th2 responses-without adverse reactions such as lymphopenia or inflammatory responses. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：1037 / 1047

页数：11

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