Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams.

被引:29
作者
Baussanne, I [1 ]
Royer, J [1 ]
机构
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
关键词
D O I
10.1016/S0040-4039(97)10746-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic alpha,beta-unsaturated-gamma-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:845 / 848
页数:4
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