Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams.

被引：29

作者：

Baussanne, I ^{[1
]}

Royer, J ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)10746-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic alpha,beta-unsaturated-gamma-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：845 / 848

页数：4

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