Epidermal growth factor receptor: mechanisms of activation and signalling

被引：1254

作者：

Jorissen, RN

Walker, F

Pouliot, N

Garrett, TPJ

Ward, CW

Burgess, AW ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Parkville, Vic, Australia

[2] CSIRO, Hlth Sci & Nutr, Parkville, Vic 3052, Australia

[3] Cooperat Res Ctr Cellular Growth Factors, Parkville, Vic 3050, Australia

[4] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

来源：

EXPERIMENTAL CELL RESEARCH | 2003年 / 284卷 / 01期

关键词：

D O I：

10.1016/S0014-4827(02)00098-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：31 / 53

页数：23

共 299 条

[91] NONCATALYTIC ACTIVATION OF PHOSPHOLIPASE C-GAMMA(1) IN-VITRO BY EPIDERMAL GROWTH-FACTOR RECEPTOR
HERNANDEZSOTOMAYOR, SMT
CARPENTER, G
[J]. BIOCHEMICAL JOURNAL, 1993, 293 : 507 - 511
[92] Ras-independent activation of Ral by a Ca2+-dependent pathway
Hofer, F
Berdeaux, R
Martin, GS
[J]. CURRENT BIOLOGY, 1998, 8 (14) : 839 - 842
[93] Thermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity
Holbrook, MR
Slakey, LL
Gross, DJ
[J]. BIOCHEMICAL JOURNAL, 2000, 352 : 99 - 108
[94] A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
Holland, EC
Hively, WP
DePinho, RA
Varmus, HE
[J]. GENES & DEVELOPMENT, 1998, 12 (23) : 3675 - 3685
[95] EVIDENCE THAT AUTOPHOSPHORYLATION OF SOLUBILIZED RECEPTORS FOR EPIDERMAL GROWTH-FACTOR IS MEDIATED BY INTERMOLECULAR CROSS-PHOSPHORYLATION
HONEGGER, AM
KRIS, RM
ULLRICH, A
SCHLESSINGER, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) : 925 - 929
[96] EVIDENCE FOR EPIDERMAL GROWTH-FACTOR (EGF)-INDUCED INTERMOLECULAR AUTOPHOSPHORYLATION OF THE EGF RECEPTORS IN LIVING CELLS
HONEGGER, AM
SCHMIDT, A
ULLRICH, A
SCHLESSINGER, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 4035 - 4044
[97] Regulation of phospholipase D by phosphorylation-dependent mechanisms
Houle, MG
Bourgoin, S
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1999, 1439 (02): : 135 - 150
[98] The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells
Huang, C
Liu, JL
Haudenschild, CC
Zhan, X
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25770 - 25776
[99] Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction
Huang, GC
Ouyang, XM
Epstein, RJ
[J]. BIOCHEMICAL JOURNAL, 1998, 331 : 113 - 119
[100] The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
Huang, HJS
Nagane, M
Klingbeil, CK
Lin, H
Nishikawa, R
Ji, XD
Huang, CM
Gill, GN
Wiley, HS
Cavenee, WK
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (05) : 2927 - 2935

← 5 6 7 8 9 10 11 12 13 14 →