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Epidermal growth factor receptor: mechanisms of activation and signalling

被引：1254
作者：
Jorissen, RN
Walker, F
Pouliot, N
Garrett, TPJ
Ward, CW
Burgess, AW [1 ]
机构：
[1] Ludwig Inst Canc Res, Parkville, Vic, Australia
[2] CSIRO, Hlth Sci & Nutr, Parkville, Vic 3052, Australia
[3] Cooperat Res Ctr Cellular Growth Factors, Parkville, Vic 3050, Australia
[4] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia
来源：
EXPERIMENTAL CELL RESEARCH | 2003年 / 284卷 / 01期
关键词：
D O I：
10.1016/S0014-4827(02)00098-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes. (C) 2003 Elsevier Science (USA). All rights reserved.
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收藏
页码：31 / 53
页数：23
相关论文
共 299 条
  • [101] Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
    Hubbard, SR
    [J]. EMBO JOURNAL, 1997, 16 (18) : 5572 - 5581
  • [102] Autoregulatory mechanisms in protein-tyrosine kinases
    Hubbard, SR
    Mohammadi, M
    Schlessinger, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (20) : 11987 - 11990
  • [103] Hudson LG, 1998, MICROSC RES TECHNIQ, V43, P444, DOI 10.1002/(SICI)1097-0029(19981201)43:5<444::AID-JEMT10>3.0.CO
  • [104] 2-C
  • [105] Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
    Hughes, PE
    Renshaw, MW
    Pfaff, M
    Forsyth, J
    Keivens, VM
    Schwartz, MA
    Ginsberg, MH
    [J]. CELL, 1997, 88 (04) : 521 - 530
  • [106] HUMPHREY PA, 1988, CANCER RES, V48, P2231
  • [107] HURWITZ DR, 1991, J BIOL CHEM, V266, P22035
  • [108] The conformational plasticity of protein kinases
    Huse, M
    Kuriyan, J
    [J]. CELL, 2002, 109 (03) : 275 - 282
  • [109] Regulation of cell migration by the calcium-dependent protease calpain
    Huttenlocher, A
    Palecek, SP
    Lu, Q
    Zhang, WL
    Mellgren, RL
    Lauffenburger, DA
    Ginsberg, MH
    Horwitz, AF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) : 32719 - 32722
  • [110] Jaks and stats in cytokine signaling
    Ihle, JN
    Nosaka, T
    Thierfelder, W
    Quelle, FW
    Shimoda, K
    [J]. STEM CELLS, 1997, 15 : 105 - 111
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