Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness

被引:88
作者
Coccaro, EF
Kavoussi, RJ
Trestman, RL
Gabriel, SM
Cooper, TB
Siever, LJ
机构
[1] Med Coll Penn & Hahnemann Univ, Sch Med, Dept Psychiat, Philadelphia, PA 19129 USA
[2] CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
[3] Nathan S Kline Inst Psychiat Res, Analyt Psychopharmacol Lab, Orangeburg, NY 10962 USA
关键词
serotonin; aggression; cerebrospinal fluid 5-HIAA; fenfluramine; m-CPP;
D O I
10.1016/S0165-1781(97)00108-X
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Three central indices of serotonin (5-HT) system activity in human subjects were examined to: (a) estimate intercorrelations among 5-HT indices and (b) compare correlations of these indices with a measure of assaultiveness (Buss-Durkee 'Assault') in personality-disordered individuals. Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentration and prolactin responses to m-chlorophenylpiperazine (m-CPP) m-CPP (PRL[m-CPP]) and fenfluramine (PRL[FEN]), served as indices of pre-, post- and 'net'-synaptic central 5-HT activity, respectively. PRL[D,L-FEN] responses were inversely related to CSF 5-HIAA concentration and positively correlated with PRL[m-CPP] responses. Both PRL[D,L-FEN] and PRL[m-CPP] response data correlated equally, and inversely, with ED Buss-Durkee Assault when the same subjects were examined. Basal CSF 5-HIAA concentration did not correlate with Buss-Durkee 'Assault'. PRL responses to challenge probes which involve activation of 5-HT post-synaptic receptors may correlate better than a basal measure of pre-synaptic 5-HT function with a tendency to assaultive behavior in non-criminally aggressive personality-disordered individuals. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:1 / 14
页数:14
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