Reversible sugar transfer by glycosyltransferases as a tool for natural product (bio)synthesis

被引：21

作者：

Bode, Helge B. ^{[1
]}

Mueller, Rolf ^{[1
]}

机构：

[1] Univ Saarland, Inst Pharmaceut Biotechnol, D-66041 Saarbrucken, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 13期

关键词：

aglycon exchange; glycosylation; natural products; sugar exchange; transferases; IN-VITRO GLYCORANDOMIZATION; UNNATURAL GLYCOSIDES; BIOSYNTHESIS; STRATEGIES; IMPACT; VINC;

D O I：

10.1002/anie.200604671

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

(Figure Presented) A bit of give and take: The recently described reversibility of sugar transfer by glycosyltransferases allows the exchange of sugar or aglycon moieties resulting in the formation of novel glycosylated compounds in a one-pot reaction (see picture; NDP=nucleoside diphosphate, GT=glycosyltransferase). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2147 / 2150

页数：4

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