A role for inflammatory mediators in the IL-18 mediated attenuation of UP in the rat dentate gyrus

被引：39

作者：

Cumiskey, D. ^{[1
]}

Curran, B. P. ^{[1
]}

Herron, C. E. ^{[1
]}

O'Connor, J. J. ^{[1
]}

机构：

[1] UCD Sch Biomol & Biomed, UCD Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

来源：

NEUROPHARMACOLOGY | 2007年 / 52卷 / 08期

关键词：

interleukin-18; long-term potentiation; PPARy; COX-2; iNOS;

D O I：

10.1016/j.neuropharm.2007.03.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pro-inflammatory cytokines are known to be elevated in several pathological conditions that are associated with deficits in cognition. We have previously demonstrated that interleukin-18 (IL-18) inhibits long-term potentiation (LTP) in the dentate gyrus in vitro. In this study we have examined the involvement of the inflammatory mediators COX-2 and iNOS in IL-18-mediated inhibition of LTR The effect of an anti-inflammatory PPAR gamma agonist was also investigated. We report that the impairment of UP by IL-18 is significantly attenuated by prior application of the COX-2 inhibitor, SC-236 and the iNOS inhibitor 1400W. These agents had no effect on paired pulse depression in the dentate gyrus. Furthermore, application of the PPAR gamma agonist ciglitazone also attenuated IL-18-mediated inhibition of LTR We discuss a role for p38 MAP kinase in these effects. This study provides novel evidence for the involvement of inflammatory mediators in IL-18-mediated inhibition of LTP in the rat dentate gyrus in vitro. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1616 / 1623

页数：8

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