Synthesis of 3′-deuterated pyrimidine nucleosides via stereoselective reduction of a protected 3-oxoribose

被引：8

作者：

Chen, TQ ^{[1
]}

Greenberg, MM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10815-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thymidine (2) and 5-methyl-2'-O-(t-butyldimethylsilyl)uridine (3) deuterated at the C3'-position were prepared with complete stereocontrol via (NaBH4)-H-2 reduction of a 3-oxoribose derivative (5). Utilization of benzyl protecting groups in the deuterated glycosidation substrate facilitates the synthesis of ribonucleosides and 2'-deoxyribonucleosides with minimal protecting group manipulations. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1103 / 1106

页数：4

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