Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon

被引：189

作者：

Tascon, RE ^{[1
]}

Stavropoulos, E ^{[1
]}

Lukacs, KV ^{[1
]}

Colston, MJ ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 02期

关键词：

D O I：

10.1128/IAI.66.2.830-834.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex: class Ii knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were incapable of making gamma interferon (IFN-gamma), it was shown that IFN-gamma production was essential for CD8 cell mediation of protective immunity against M. tuberculosis.

引用

页码：830 / 834

页数：5

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