Reactions of 1-methylbenzimidazole derivatives with m-chloroperoxybenzoic acid

被引：13

作者：

Kaiya, T ^{[1
]}

Aoyama, S ^{[1
]}

Kohda, K ^{[1
]}

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 467, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(98)00082-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxidation of seven 1-methylbenzimidazole (MBI) derivatives (with pKa's ranging from 1.6 to 6.0) was carried out with m-chloroperoxybenzoic acid and structures of the products formed were identified. (Condensed benzene moiety-hydroxylated)-2-(m-chlorobenzyloxy)-MBIs and 2-oxo-MBIs were obtained from MBIs with pKa's of more than 5.6 and about 3.3, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：625 / 630

页数：6

共 17 条

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