Fluorescence resonance energy transfer as a structural tool for nucleic acids

被引：124

作者：

Lilley, DMJ ^{[1
]}

Wilson, TJ ^{[1
]}

机构：

[1] Univ Dundee, Dept Biochem, CRC, Nucl Acid Struct Res Grp, Dundee DD1 4HN, Scotland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(00)00124-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorescence resonance energy transfer is a spectroscopic method that provides distance information on macromolecules in solution in the range 20-80 Angstrom. It is particularly suited to the analysis of the global structure of nucleic acids because the long-range distance information provides constraints when modelling these important structures. The application of fluorescence resonance energy transfer to nucleic acid structure has seen a resurgence of interest in the past decade, which continues to increase. An especially exciting development is the recent extension to single-molecule studies.

引用

页码：507 / 517

页数：11

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