Mouse models with modified p53 sequences to study cancer and ageing

被引：14

作者：

Clarke, AR

Hollstein, M

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff F10 3US, S Glam, Wales

[2] German Canc Res Ctr, Heidelberg, Germany

来源：

CELL DEATH AND DIFFERENTIATION | 2003年 / 10卷 / 04期

关键词：

transgenic; p53; Cre-Lox; ageing; neoplasia; murine;

D O I：

10.1038/sj.cdd.4401188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experiments with p53 transgenic and p53 gene-targeted mouse strains have substantiated, and in some cases challenged, a number of hypotheses on the biology of the p53 protein. New questions have emerged regarding similarities and differences between murine and human genetic networks in various tissues. Mouse models with targeted p53 alleles are now applied not only to investigate tumour susceptibility, but also to address questions pertinent to molecular epidemiology, chemoprevention, development of anticancer p53-specific pharmaceuticals, and ageing.

引用

收藏

页码：443 / 450

页数：8

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