A possible prolactin-related adverse effect of certain antineoplastic anthracyclines

被引：4

作者：

Brunetti, L

Orlando, G

Michelotto, B

Recinella, L

Ragazzoni, E

Vacca, M

机构：

[1] Univ G DAnnunzio, Dept Drug Sci, I-66013 Chieti, Italy

[2] Catholic Univ Rome, Inst Pharmacol, Rome, Italy

来源：

TOXICOLOGY LETTERS | 2000年 / 116卷 / 03期

关键词：

anthracyclines; daunorubicin; doxorubicin; epirubicin; prolactin (PRL); pituitary;

D O I：

10.1016/S0378-4274(00)00223-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Nonhormonal antineoplastic therapy can affect the endocrine system with consequent effects on the growth of hormone-sensitive tumors. Amongst anthracycline antibiotics, we have found daunorubicin and epirubicin able to acutely stimulate prolactin (PRL) secretion both in vivo, in the rat, and in vitro, from rat anterior pituitary cell cultures. Despite a similar structure, doxorubicin showed no such activity. Considering the possible role of PRL in breast cancer cell proliferation, the effects of certain anthracyclines might be viewed as an adverse drug reaction involving the anterior pituitary gland. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：231 / 236

页数：6

共 12 条

[1] Immune-neuro-endocrine interactions: Facts and hypotheses [J].