Direction control in DNA binding of chiral D-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

被引：27

作者：

Sforza, S ^{[1
]}

Tedeschi, T ^{[1
]}

Corradini, R ^{[1
]}

Dossena, A ^{[1
]}

Marchelli, R ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 09期

关键词：

D O I：

10.1039/b212718k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The DNA binding abilities of peptide nucleic acids (PNAs), both achiral and bearing three adjacent D-lysine-based monomers in the middle of the strand ("chiral box" PNA), were studied by means of electrospray mass spectrometry (ESI-MS). In contrast with achiral PNA, "Chiral box" PNA was confirmed to exert high direction control (antiparallel vs. parallel DNA target) in DNA binding.

引用

页码：1102 / 1103

页数：2

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