Sec-translocase mediated membrane protein biogenesis

被引:79
作者
Dalbey, RE [1 ]
Chen, MY [1 ]
机构
[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1694卷 / 1-3期
关键词
SecYEG; membrane protein insertions membrane protein assembly; protein targeting; membrane translocation;
D O I
10.1016/j.bbamcr.2004.03.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
a-Helical transmembrane proteins in bacteria are localized within the plasma membrane. The membrane assembly of these proteins requires protein devices for insertion into the lipid bilayer. In E. coli, membrane proteins require the SRP pathway components Ffh. 4.5S RNA and FtsY for membrane targeting and the SecYEGDF translocase and. in some cases. SecA. for translocation of hydrophilic domains. In addition, YidC, a recently discovered membrane protein, mediates the membrane integration and folding of hydrophobic domains of membrane proteins. In this review, we will describe the current status of the protein targeting and membrane integration pathways. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:37 / 53
页数:17
相关论文
共 162 条
[1]   Structure and mechanism of the lactose permease of Escherichia coli [J].
Abramson, J ;
Smirnova, I ;
Kasho, V ;
Verner, G ;
Kaback, HR ;
Iwata, S .
SCIENCE, 2003, 301 (5633) :610-615
[2]   The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli [J].
Adams, H ;
Scotti, PA ;
de Cock, H ;
Luirink, J ;
Tommassen, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (22) :5564-5571
[3]   RECONSTITUTION OF A PROTEIN TRANSLOCATION SYSTEM CONTAINING PURIFIED SECY, SECE, AND SECA FROM ESCHERICHIA-COLI [J].
AKIMARU, J ;
MATSUYAMA, SI ;
TOKUDA, H ;
MIZUSHIMA, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (15) :6545-6549
[4]   Subunit a of proton ATPase F-0 sector is a substrate of the FtsH protease in Escherichia coli [J].
Akiyama, Y ;
Kihara, A ;
Ito, K .
FEBS LETTERS, 1996, 399 (1-2) :26-28
[5]   Roles of multimerization and membrane association in the proteolytic functions of FtsH (HflB) [J].
Akiyama, Y ;
Ito, K .
EMBO JOURNAL, 2000, 19 (15) :3888-3895
[6]  
ALLARD JD, 1992, J BIOL CHEM, V267, P17809
[7]   The Saccharomyces cerevisiae OXA1 gene is required for the correct assembly of cytochrome c oxidase and oligomycin-sensitive ATP synthase [J].
Altamura, N ;
Capitanio, N ;
Bonnefoy, N ;
Papa, S ;
Dujardin, G .
FEBS LETTERS, 1996, 382 (1-2) :111-115
[8]  
ANDERSON HR, 1993, PAEDIATRIC RESPIRATO, V1, P6
[9]   MEMBRANE-PROTEIN TOPOLOGY - EFFECTS OF DELTA-MU(H)+ ON THE TRANSLOCATION OF CHARGED RESIDUES EXPLAIN THE POSITIVE INSIDE RULE [J].
ANDERSSON, H ;
VONHEIJNE, G .
EMBO JOURNAL, 1994, 13 (10) :2267-2272
[10]   A 30-RESIDUE-LONG EXPORT INITIATION DOMAIN ADJACENT TO THE SIGNAL SEQUENCE IS CRITICAL FOR PROTEIN TRANSLOCATION ACROSS THE INNER MEMBRANE OF ESCHERICHIA-COLI [J].
ANDERSSON, H ;
VONHEIJNE, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9751-9754