Unusual RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide mimic (POM)

被引：41

作者：

Hickman, DT

King, PM

Cooper, MA

Slater, JM

Micklefield, J

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs, England

[2] Univ London Birkbeck Coll, Dept Chem, London WC1H 0PP, England

[3] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 22期

关键词：

D O I：

10.1039/b006903p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pentameric thymidyl pyrrolidine-amide oligonucleotide mimic (POM) was synthesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.

引用

页码：2251 / 2252

页数：2

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