Evolution of MRSA During Hospital Transmission and Intercontinental Spread

被引：853

作者：

Harris, Simon R. ^{[1
]}

Feil, Edward J. ^{[2
]}

Holden, Matthew T. G. ^{[1
]}

Quail, Michael A. ^{[1
]}

Nickerson, Emma K. ^{[3
,4
]}

Chantratita, Narisara ^{[3
]}

Gardete, Susana ^{[5
,6
]}

Tavares, Ana ^{[5
]}

Day, Nick ^{[3
,7
]}

Lindsay, Jodi A. ^{[8
]}

Edgeworth, Jonathan D. ^{[9
,10
]}

de Lencastre, Herminia ^{[5
,6
]}

Parkhill, Julian ^{[1
]}

Peacock, Sharon J. ^{[3
,4
]}

Bentley, Stephen D. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 15A, England

[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[3] Mahidol Univ, Fac Trop Med, Bangkok, Thailand

[4] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 0QQ, England

[5] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, Portugal

[6] Rockefeller Univ, Microbiol Lab, New York, NY 10065 USA

[7] Univ Oxford, Nuffield Dept Clin Med, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

[8] Univ London, Dept Cellular & Mol Med, Ctr Infect, London SW17 0RE, England

[9] Guys Hosp, Guys Kings & St Thomas Med Sch, Kings Coll London, Dept Infect Dis, London SE1 9RT, England

[10] Guys & St Thomas Natl Hlth Serv Fdn Trust, Directorate Infect, London SE1 7EH, England

来源：

SCIENCE | 2010年 / 327卷 / 5964期

基金：

英国惠康基金;

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; IDENTIFICATION; CLONES; TRIMETHOPRIM; MUTATION; STRAIN;

D O I：

10.1126/science.1182395

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

引用

页码：469 / 474

页数：6

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