Microwave-assisted Michael addition of some pyrimidine and purine nucleobases with α,β-unsaturated esters:: A rapid entry into carboacyclic nucleoside synthesis

被引：67

作者：

Khalafi-Nezhad, A ^{[1
]}

Zarea, A ^{[1
]}

Rad, MNS ^{[1
]}

Mokhtari, B ^{[1
]}

Parhami, A ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

SYNTHESIS-STUTTGART | 2005年 / 03期

关键词：

D O I：

10.1055/s-2004-834950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure for the synthesis of some carboacyclic nucleosides via microwave-assisted Michael addition of various nucleobases to alpha, beta-unsaturated esters in the presence of tetrabutylammonium bromide (TBAB) and DABCO is described. Using this method, some pyrimidine and purine nucleobases have been alkylated regioselectively in moderate to high yields and short reaction time.

引用

页码：419 / 424

页数：6

共 59 条

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AHLUWALIA VK, 2001, ORGANIC SYNTHESIS SP, P90

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