Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D

被引：114

作者：

Dimeloe, Sarah

Nanzer, Alexandra

Ryanna, Kimuli

Hawrylowicz, Catherine ^{[1
]}

机构：

[1] Kings Coll London, Ctr Allerg Mech Asthma, Guys Hosp, MRC, London SE1 9RT, England

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 120卷 / 2-3期

关键词：

Asthma; Allergy; Tolerance; Glucocorticoids; Vitamin D; Regulatory T cells (TRegs); CATHELICIDIN ANTIMICROBIAL PEPTIDE; IMMUNOLOGICAL SELF-TOLERANCE; SERUM 25-HYDROXYVITAMIN D; 3RD NATIONAL-HEALTH; TOLL-LIKE RECEPTORS; 1,25-DIHYDROXYVITAMIN D-3; CUTTING EDGE; AIRWAY INFLAMMATION; MULTIPLE-SCLEROSIS; D SUPPLEMENTATION;

D O I：

10.1016/j.jsbmb.2010.02.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：86 / 95

页数：10

相关论文

共 176 条

[1] Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer - results of a large case-control study [J].

Abbas, Sascha ;

Linseisen, Jakob ;

Slanger, Tracy ;

Kropp, Silke ;

Mutschelknauss, Elke Jonny ;

Flesch-Janys, Dieter ;

Chang-Claude, Jenny .

CARCINOGENESIS, 2008, 29 (01) :93-99

[2] Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses [J].

Adams, John S. ;

Ren, Songyang ;

Liu, Philip T. ;

Chun, Rene F. ;

Lagishetty, Venu ;

Gombart, Adrian F. ;

Borregaard, Niels ;

Modlin, Robert L. ;

Hewison, Martin .

JOURNAL OF IMMUNOLOGY, 2009, 182 (07) :4289-4295

[3] Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands [J].

Adorini, L ;

Penna, G ;

Giarratana, N ;

Roncari, A ;

Amuchastegui, S ;

Daniel, KC ;

Uskokovic, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 89-90 (1-5) :437-441

[4] Control of autoimmune diseases by the vitamin D endocrine system [J].

Adorini, Luciano ;

Penna, Giuseppe .

NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2008, 4 (08) :404-412

[5]

Adorini Luciano, 2009, Handb Exp Pharmacol, P251, DOI 10.1007/978-3-540-71029-5_12

[6] Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three [J].

Ait-Khaled, N. ;

Pearce, N. ;

Anderson, H. R. ;

Ellwood, P. ;

Montefort, S. ;

Shah, J. .

ALLERGY, 2009, 64 (01) :123-148

[7] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].

Akdis, M ;

Verhagen, J ;

Taylor, A ;

Karamloo, F ;

Karagiannidis, C ;

Crameri, R ;

Thunberg, S ;

Deniz, G ;

Valenta, R ;

Fiebig, H ;

Kegel, C ;

Disch, R ;

Schmidt-Weber, CB ;

Blaser, K ;

Akdis, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1567-1575

[8] Therapeutic manipulation of immune tolerance in allergic disease [J].

Akdis, Muebeccel ;

Akdis, Cezmi A. .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (08) :645-660

[9] TH17-associated cytokines (IL-17A and IL-17F) in severe asthma [J].

Al-Ramli, Wisam ;

Prefontaine, David ;

Chouiali, Fazila ;

Martin, James G. ;

Olivenstein, Ron ;

Lamiere, Catherine ;

Hamid, Qutayba .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (05) :1185-1187

[10] Fel d 1-derived T cell peptide therapy induces recruitment of CD4+CD25+;: CD4+ interferon-γ+ T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects [J].

Alexander, C ;

Ying, S ;

Kay, AB ;

Larché, M .

CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (01) :52-58

← 1 2 3 4 5 6 7 8 9 10 →