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Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D

被引：114
作者：
Dimeloe, Sarah
Nanzer, Alexandra
Ryanna, Kimuli
Hawrylowicz, Catherine [1 ]
机构：
[1] Kings Coll London, Ctr Allerg Mech Asthma, Guys Hosp, MRC, London SE1 9RT, England
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 120卷 / 2-3期
关键词：
Asthma; Allergy; Tolerance; Glucocorticoids; Vitamin D; Regulatory T cells (TRegs); CATHELICIDIN ANTIMICROBIAL PEPTIDE; IMMUNOLOGICAL SELF-TOLERANCE; SERUM 25-HYDROXYVITAMIN D; 3RD NATIONAL-HEALTH; TOLL-LIKE RECEPTORS; 1,25-DIHYDROXYVITAMIN D-3; CUTTING EDGE; AIRWAY INFLAMMATION; MULTIPLE-SCLEROSIS; D SUPPLEMENTATION;
D O I：
10.1016/j.jsbmb.2010.02.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：86 / 95
页数：10
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