Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS

被引：23

作者：

Ahlers, Jeffrey D. ^{[1
]}

Belyakov, Igor M. ^{[2
]}

机构：

[1] NIAID, NIH, Bethesda, MD 20817 USA

[2] Midwest Res Inst, Frederick, MD 21702 USA

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; VIRAL REPLICATION CAPACITY; IMMUNE ESCAPE; MUCOSAL IMMUNIZATION; LYMPHOCYTE EPITOPES; ELITE CONTROLLERS; HIV-INFECTION; HIGH-AVIDITY; V-BETA; RESPONSES;

D O I：

10.1016/j.it.2009.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8(+) CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major question for vaccine design is whether incorporating epitopes responsible for controlling a persistent virus will translate into protection from natural infection or serve solely as a fail-safe mechanism to prevent overt disease in infected individuals. Here, we discuss qualitative parameters of the CD8(+) CTL response and mechanisms operative in the control of persistent virus infections and suggest new strategies for design and delivery of HIV vaccines.

引用

页码：120 / 130

页数：11

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